Treating Autism With Stem Cells in India

Autism is a spectrum of neuro-degenerating conditions affecting each child with autism with different symptoms. This group of developmental disabilities interferes with the development of essential skills comprising of intellectual disabilities, behavioural issues, and difficulties in communicating and socializing. In autism, the network of brain cells (neurons or nerve cells) does not function properly, thereby impairing the complete neuron system. 

Adult stem cells, found in the tissue of the bone marrow, can divide and generate into large quantities of cells. These cells are therefore harnessed for autism treatment for generating innumerable cells for treating/replacing the damaged brain cells. 

Treatment 

Neurogen Brain and Spine Institute in Mumbai uses mesenchymal stem cells extracted from the hip bone of the patient for brain-tissue treating purposes. The treatment is done by a team of renowned doctors, therapists, and neurosurgeons who dedicatedly serve to provide their patients with an independent and enhanced lifestyle. 

Cell therapy for autism in India is done at Neurogen BSI where they treat not only Indians but also patients from various countries. Before treatment, the neurosurgeons consult with the parents or caregivers of the patients to know in-depth about their past medical history and symptoms. They perform several tests to understand the stage of disease and the severity of the condition. As per the test results, the doctors discuss autism treatment with family members, enlightening them about the cell treatment procedure and its benefits. 

Cell therapy for autism in India is a simple and painless procedure. Initially, the neurosurgeon extract stem cells from the patient’s hip bone with an aspiration needle. This extracted marrow is sent to the well-equipped GMP laboratory for processing. The stem cells are separated from the marrow tissue and tested for faults. The last step of the therapy for autism treatment is the patient receiving the stem cells via intrathecal injection in the spinal area. As these cells belong to the patient, they have no chance of being rejected or causing dire reactions. The transplant is always successful.

 Post-treatment the doctors suggest rehabilitation programs (according to the need of each patient), that involve occupational therapy, speech therapy, physiotherapy, and ABA therapy. 

The neurosurgeons at Neurogen BSI believe that every patient deserves an effective and safe treatment. They pledge to provide the next-generation treatments along with state of the art facility with matchless services to assure valuable treatment results. 

Why Stem Cells Work Best For Cerebral palsy

Extensive research has led to the conclusion that transplantation of autologous stem cells is a promising treatment to improve and reverse neurological and muscular damages and also prevent secondary complications from arising.  

Cell treatment, employed at Neurogen BSI to treat patients with cerebral palsy, has shown promising results. They employ autologous mesenchymal stem cells (extracted from the bone marrow) to treat cerebral palsy patients. The potential of mesenchymal cell treatment are:

1. Reduce the inflammatory reaction
2. Avoid secondary brain lesion
3. Can differentiate into neurons, microglia, and astrocyte to promote axon regeneration, and repair the myelin sheath
4.  Produce cytokines and nerve growth factors, to promote neuroprotection
5. Generate new blood vessels and thus, increase sufficient oxygen and nutrient supply to the injured tissue
6. Reduce intrinsic cell apoptosis

Cerebral palsy treatment in India’s Neurogen BSI provides easy access to patients with cerebral palsy. They provide the best treatment plans that begin with extensive medical evaluation and a complete treatment understanding which involves stem cells. The service here is provided by the best neurosurgeons and trained staff. 

Promising Improvements

Treatment for cerebral palsy, using a combination of cell therapy and supportive or rehabilitation therapies, have shown visible improvements in patients. Cerebral palsy treatment in India has helped to regain motor development and limb coordination, recover impaired vision and cognitive skills, increase muscle strength, and decrease spasticity. A notable improvement is also seen in fine and gross motor skills due to improved muscle tone.

Cerebral Palsy treatment with stem cells has proved an improvement in areas such as:

• Motor function
• Limb coordination
• Eyesight 
• Muscular Strength
• Epilepsy
• Swallowing
• Communication skill 

Moreover, treatment with stem cells releases the growth factors which promote cell growth, regulates immune response, and stimulation the brain cells to accelerate recovery of brain plasticity.

Supportive Therapies 

After cell therapy, neurosurgeons also prescribe supportive therapies or immune-enhancing programs to get the most out of the infused stem cells. Some of the programs included in the agenda are:

• Hyperbaric Oxygen Chamber (HBOT)
• Occupational therapy
• Aquatic therapy
• Physiotherapy treatment
• Special diet plans 
• Psychological intervention

 The staff at Neurogen BSI believe that each visiting patient (with cerebral palsy or other neurodegenerative disorders) deserve an effective and safe treatment. They provide the next-generation treatments, within the best in-house facilities and services that are integrative to ensure the best possible treatment results.

Mesenchymal Stem Cells - An Anti-Inflammatory Treatment for Muscular Dystrophy

Duchenne muscular dystrophy is a progressive and lethal muscular-degenerative condition which is caused by the mutation of the dystrophin gene. Cell therapy for muscular dystrophy is the only intervention that can mediate improvement in patients. 

Without the essential dystrophin, muscle fibres are highly vulnerable to damage and easy succumbing, affecting the normal daily activities in patients.  This muscle damage is easily repaired with autologous mesenchymal stem cells that have the potential to address this progressive degeneration in muscular dystrophy muscles. Thus, cell transplantation is the best muscular dystrophy treatment approach to reverse the damage of degenerated muscle-cells in patients with muscular dystrophy.

Mesenchymal stem cells are multipotent cells that can be easily sourced from the marrow tissue. They have the capacity to repair bone, brain cell tissue, blood vessel, and muscular-skeletal tissue. These cells have shown great promise for patients with muscular dystrophy in NeuroGen BSI hospital where the neurosurgeons confirm the safety of muscular dystrophy treatment with intrathecal injection of mesenchymal stem cells in the spinal area.

The trained surgeons and staff at the NeuroGen BSI  have stated amazing symptomatic improvement in 90% of their muscular dystrophy patients.  They have a vast experience of treating individuals with degenerative muscle diseases, spinal cord injury and those disturbed with neurological conditions. Thus, mesenchymal cell therapy for muscular dystrophy is an emerging regenerative medicine that focuses on treatment providing improved limb and muscle coordination.

People who inquire about the advantage of cell treatment with mesenchymal stem cells (in contrast to other cell-based therapies) must know the underlying benefits:  

• The ability to fuse and genetically balance dystrophic deficiency in muscle
• They possess anti-inflammatory factors
• They produce trophic factors that enhance the activity of cell repair

With the above-mentioned properties, the neurosurgeons prefer mesenchymal stem cell therapy for muscular dystrophy as they have the advantages of correcting the dystrophin deficiency in muscle cells and also in regaining the muscle tone, flexibility, strength and a balanced gait.

Stem Cell Transplantation For Spinal Cord Injury: A Promising Treatment

Spinal cord injury is the most difficult traumatic neurological condition that is caused due to primary injury to the spinal cord. This results in structural damage, including haemorrhage, demyelination, edema, and brain trauma. Cell treatment for spinal cord injury provides neuroprotective effects and neuroregeneration potential.

Types and Symptoms Of Spinal Cord Injury

Symptoms in each individual with spinal cord injury vary according to the area and the severity of the injury.  They are based on the type of injury, such as:

• Complete Injury: There is no movement or sensation below the site of injury
• Incomplete Injury: There is still some movement felt in areas below the point of injury

Symptoms of spinal cord injury also depend on the site that is injured. For instance:

• Injury to the neck (cervical): An individual with cervical injury experience sensory damage, loss of muscle strength in limbs and loss of sensation below the point of injury.
• Injury to the upper spinal cord (thoracic): This results in weak chest muscles and the individual may need a ventilator to breathe.
• Injury to the lower spinal cord (lumbar and sacral): An injury to this site can cause paralysis, loss of function in the lower limbs, loss of bladder and bowel control.

Stem Cells To Treat Spinal Cord Injury 

An injured spinal cord is difficult to repair through traditional managements as they are ineffective. Cell treatment for spinal cord injury involves mesenchymal stem cells sourced from the bone marrow and has the potential to differentiate into various cells, and also adopt the properties of the host cells. When infused into the body, they exert a therapeutic effect by differentiating into neurons to replace the damaged cells. They also secrete neurotrophic factors and prevent the damaging inflammatory response. The main therapeutic effects of stem cells include the astrocytes contribution to the glial scar, provide support and insulation to axons (oligodendrocyte), and repairing or replacing the missing nerve cells in spinal cord injury. These multipotent stem cells also secrete pro-regenerative factors to heal and protect the damaged tissue cells.

Cell treatment for spinal cord injury is done at NeuroGen BSI hospital based in Mumbai. They have treated over 8000 people with stem cells for various neurological disorders for which stem cells are promising applicants. Some of the incurable neurological disorders treated at NeuroGen are:

• Autism
• Stroke
• Dementia
• Head injury
• Muscular dystrophy
• Spinal cord injury
• Motor neuron disease  

The procedure of spinal cord injury cell treatment is safe and simple without having the patient to go under the knife. It just includes the extraction of the marrow from the patient’s hip bone, the separation of the stem cells from the marrow tissue and the final step is the infusion of the new stem cells in the spinal area.

When merged with the cerebrospinal fluid in the spinal area, the stem cells produce cytokines and growth factors that play an important role in promoting tissue regeneration. Based on the characteristics of stem cells, cell therapy is the most promising neuro-regenerative medicine for spinal cord injury.

Physiotherapy for Cerebral Palsy

Cerebral Palsy is a non-progressive disability which surfaces due to the damaged brain tissue during pregnancy, at birth or in early childhood stage. The injured brain tissue disrupts the nerve signals causing difficulty with activities such as movement, posture, and limb coordination. Cerebral palsy treatment in Mumbai’s Neurogen hospital depends on the extent of damage to any part of the brain.

Cerebral palsy is responsible for defects of vision and hearing; loss of speech or language skill; and lack of cognitive skill in individuals. Apart from this, they may also have:

• Various behavioral problems
• Learning problems and difficulties in communication
• Epilepsies or intellectual impairment
• Retarded development of language that affects speech
• Inability to perform certain actions such as movement of the limbs, face, eyes that restrict them from dressing, writing or drawing

Types of Cerebral Palsy

Based on the area of brain damage, cerebral palsy is categorized as:

• Spastic cerebral palsy 
•  Dyskinetic (athetoid) cerebral palsy  
• Ataxic cerebral palsy
• Hypotonic cerebral palsy
• Mixed cerebral palsy

Cerebral Palsy Management

Proper management of cerebral palsy requires various tests to determine the functional capacity of the individual. It also evaluates the nature and extent of its various deficit. The management is accomplished by:

• Paediatrician specialized in Neuro-developmental conditions
• Physiotherapist
• Occupational therapist

Treatment

Cerebral Palsy treatment in Mumbai is done by renowned neurosurgeons of Neurogen hospital. Treatment with the autologous bone marrow-derived stem cells present no side effects without or fear of immune rejection.  Stem cells have the capability to:

• Replace the damaged cells and prevent further cell death
• Establish a new neuron map in order to revive essential skills
• Create new blood vessels for providing fresh blood supply to the brain

The hospital proudly states to have treated more than1286 patient.

Physiotherapy for Cerebral Palsy

Post stem cell treatment for cerebral palsy physiotherapy set goal is aimed at promoting physical development and escalating mobility in individuals. At Neurogen hospital, the trained and experienced physiotherapists diagnose the problem to create a well-tailored treatment program according to the specific needs of each child. Physiotherapy treatment programs aim to restore function and minimize the dysfunction of cerebral palsy. This is achieved through a combination of manual therapy, exercises, and assistive devices.

Physiotherapy treatments offered at the hospital is aimed at:

• Increasing muscle strength
• Improve mobility
• Physical progress through exercises and play activities
• Ease muscles tightness and spasms through various programs and techniques
• To reduce abnormal patterns of movement
• Improve balance and mobility
• Reduce the risk of falls 

For cerebral palsy physiotherapy increases independence living and quality of life in individuals through proper management.

Mesenchymal Stem Cell For Stroke Treatment

A stroke occurs when the blood supply to the brain gets blocked due to blood clots or ruptured blood vessels. As the brain does not receive the needed oxygen and nutrients, the cells begin to die, hampering the body functionality. The best way to prevent stroke is by maintaining a healthy lifestyle and immediate medical attention for treating underlying risk factors.

Symptoms

Few of the symptoms of stroke are:

• Headache accompanied, at times, with loss of consciousness
• Paralysis
• Difficulty while seeing in one or both the eyes
• Trouble speaking and understanding language
• Dizziness 
• Depression
• Pain in the limb that worsens with movement

The two main types of strokes are:

• Ischemic strokes caused by blocked and narrow arteries. 
• Hemorrhagic strokes caused by ruptured or bleeding arteries in the brain.

Stem cell-based approach is a tool for treating stroke with their therapeutic effect. The favorable effects of the autologous adult stem cells, such as neuroprotection, cell replacement, etc., along with their influence on inflammation and immune response have made them the safest and sought after treatment. For stroke cell treatment has shown high efficiency in managing the symptoms.

For stroke, stem cell treatment does not require any major operation. The adult stem cells derived from the patient’s own bone marrow (with an aspiration needle), are filtered and treated before being infused (intrathecally) back into the patient’s spinal area. With the help of the cerebrospinal fluid, they travel to the brain to induce growth factors within the damaged tissues. As the infused stem cells stimulate the damaged brain cells and induce restorative events, there is an improvement in the neurological functions. A marked functional improvement is observed in patients within days after cell treatment for stroke.

These positive effects of mesenchymal stem cells have prompted the neurosurgeons to accept them as an option for stroke treatment.

Rehabilitation

For a successful recovery after a cell treatment for stroke, the patient needs physical and emotional support to get over the trauma he/she experienced.  Therapies such as:

• Speech therapy: For communicating and language issues.  
• Physical therapy: To help the patient regain his/her limb coordination, balance, movement and to stay active.
• Occupational therapy: To develop the required abilities to carry out their daily activities, such as dressing, reading, eating, and writing.

Apart from the above-mentioned therapies, love and support from relatives and friends offer comfort to patients.

The best stem cell-based treatment is done by experienced neurosurgeons of Neurogen Brain and Spine Institute based in Mumbai. Patients from various countries come here to seek treatment for the neurological and muscular disorder. They have declared having successfully treated over 214 stroke patients and hence proved that cell treatment for stroke in India can help patients lead an independent and fulfilled life.  

Muscle Regeneration With Cell Therapy

Muscular dystrophy is a varied collection of neuromuscular disorders that result in progressive muscle weakening and wasting. The disorders differ depending on their severity and the muscle types affected. Duchenne muscular dystrophy, an X-linked genetic disorder, is a common form of muscular dystrophy.

Muscular dystrophy occurs due to spontaneous mutation or inherited mutation in the dystrophin gene which results in the loss of dystrophin protein. Dystrophin is an important cytoskeletal protein responsible for the maintenance of muscle cell stability or integrity. Without adequate dystrophin, muscle cells degenerate rendering the person helpless.

For satisfactory treatment, cell therapy for muscular dystrophy is done with autologous stem cells isolated from the patient’s bone marrow. To date, where many treatment methods have failed, stem cells with their multiple growth factors and healing potential, promote muscle regeneration. 

Cell treatment, for muscular dystrophy, has proved to be the best option to treat muscular dystrophy with success. To correct the dystrophic insufficiency, the transplanted stem cells merge with the host cells to form new myotubes. This fusion contributes to the production of functional dystrophin protein. Stem cell based therapy for muscular dystrophy is beneficial via autologous stem cell transfer strategy. For this process, the marrow is collected from the patient’s hip bone. The collected marrow tissue is filtered to separate the active stem cells. The collected stem cells are improved/treated to restore dystrophin expression and are subsequently re-implanted into the required muscle points of the patient.

Advantage Of Autologous Transplant

As autologous cell therapy for muscular dystrophy is done with stem cells derived from the patient, they are unlikely to elicit an adverse immune response. However, in an allogenic cell transplant, the patient risks immune rejection due to issues of donor compatibility.  

Neurogen Brain and Spine Institute based in Mumbai, offers the best cell treatment for muscular dystrophy and other neurological disorders such as autism, dementia, cerebral palsy and stroke. The neurosurgeons of the hospital state that 90% of improvement was seen in their patients after cell treatment.

Patients treated have shown improvement in their standing posture, trunk stability, and needed less support while walking. They exhibited an improved standing and walking balance and no more falling due to the buckling of knees. There was an increase in muscle strength of ankle muscles and the patient could climb up and down the stairs with ease and less support.

Cell Therapy For The Treatment Of Intellectual Disability

Intellectual disability is recognized in patients having both intellectual and adaptive functioning issues. It is assessed by a doctor through standardized IQ testing. An IQ score of 70 - 75 indicates the patient as being intellectually disabled. The scores can vary considerably or may also not accurately reflect his/her overall intellectual functioning. There are many degrees of intellectual disability ranging from mild to profound.

The areas of functioning impaired due to intellectual disability are:

• Conceptual: Inability to read, write, reason, remember, attention deficit
• Social: Lack of communication skill, empathy, make friends, follow rules
  

Causes 

Some of the known causes of intellectual disability are:

• Genetic conditions: Down syndrome, fragile X syndrome  
• Problems during pregnancy: Interference with fetal brain development due to excessive alcohol or drug use, and infections
• Problems during childbirth: Occurs when the baby’s brain is deprived of fresh oxygen supply or if he/she is born extremely premature
• Illness or injury: Infections like measles or meningitis can lead to intellectual disability in the newborn baby. A head injury or a near-drowning incident or exposure to toxins such as lead also lead to intellectual disability.
• Signs of intellectual disability

Given below are some of the common signs of intellectual disability:

• Late in reaching the motor milestone like sitting, crawling, rolling over, walking
• Having trouble while talking
• Slow to learn things like dressing, tying a shoelace, eating  
• Find difficult to remember things
• Behaviour problems such as tantrums
• Difficulty with logical thinking
• Health problems that include anxiety, seizures, vision and hearing issues

Intellectual Disability is a non-progressive condition that affects a person’s cognition, behaviour, and social skills. Although there is no complete cure for this condition, still cell therapy for intellectual disability focuses on the symptoms and addressing its core neurological condition. To reverse the damage caused to the brain, intellectual disability treatment, cell treatment is a neuro-restorative therapy which benefits patients in gaining the needed skills.

Autologous bone marrow mesenchymal stem cells are approved for intellectual disability treatment.  They are easily collected from the patient’s own bone marrow and have the capability to multiply into numerous cells. The treatment procedure is accomplished in Neurogen hospital in just three easy steps.

• The bone marrow is extracted with the help of an aspiration needle from the patient’s own hip bone.
• The collected marrow tissue undergoes a filtration process to separate the stem cells.
• The acquired stem cells are intrathecally introduced in the spinal area.

Once inside the body, these stem cells migrate to the damaged areas of the brain to differentiate into neurons, adopt the properties of the host cells, and accelerate the neurorestorative processes.  Thus cell therapy for intellectual disability has proved to be beneficial in minimizing the severity of the disorder.

The treatment with the bone marrow-derived stem cells in combination with rehabilitation therapies or conventional treatment such as speech therapy and occupational therapy are aimed towards improving the symptoms of intellectual disability.  The objective is to reduce the level of impairment while enhancing the functional ability of the individual.

Muscular Dystrophy Cell Treatment For Repair Of Weak Muscles

Muscular dystrophy is an assemblage of diseases that damage and gradually weaken the body muscles rendering the person helpless. The damages sets in due to the lack of a protein called dystrophin, essential for normal muscle and motor functions. The absence of dystrophin causes problems while walking, swallowing, posture, and limb coordination. Muscular dystrophy treatment involving autologous stem cells, can maintain the balance of dystrophin and strengthen the musculoskeletal muscles to produce all the required movements of the body. 

The prognosis for muscular dystrophy is based on the severity of the symptom. Most individuals lose the ability to walk and become totally dependent on supportive devices and wheelchair to move about. Although there is no known cure for muscular dystrophy, still early diagnosis and certain therapies may help in reducing the dearth of the symptoms.

Muscular Dystrophy

Muscular dystrophy is common among children.  The symptoms include:

• Irregular walking gait
• Loss of reflexes
• Difficulty standing up from sitting or sleeping position
• Poor posture
• Bone fragility
• Abnormal curvature of your spine (scoliosis)
• Intellectual impairment
• Difficulties while swallowing and breathing

If the individuals with muscular dystrophy are not provided with apt treatment, at an early stage, they may get confined to a wheelchair before they enter teenage. For muscular dystrophy cell treatment is a promising treatment option to rebuild the waning muscle and also curb further musculoskeletal deterioration.

Stem Cell-Based Therapies

Stem cells are specialized body cells found in tissues (like bone marrow) and can proliferate and replicate themselves for a long period of time. For muscular dystrophy, cell treatment is a stem cell-based therapy, responsible for the development of muscle tissues. Stem cells sourced from the patient’s own bone marrow have these properties:

• They are capable of dividing and self-renewal for a long time
• They can give rise to specialized or any cell type

Therapies with stem cells restore the skeletal muscle deficiency in individuals with muscular dystrophy by regenerating new muscle fibers. 

For muscular dystrophy treatment, the mesenchymal stem cells derived from the patient’s own bone marrow is processed in the fully equipped GLP (Good Lab Practice) & GMP (Good Medical Practice) laboratory of the Neurogen hospital. The treated stem cells are injected into the muscles using a very thin needle.

The individuals are enrolled in rehabilitation therapies, post cell therapy, for better results.

Cell Therapy - The Best Treatment For Autism

Autism is a spectrum of disorders marked with the inabilities to maintain normal communication and social interactions. It is associated with symptoms of self-stimulatory or repetitive behaviors, and also loss of interests. When these challenges interfere with a child’s normal growth, diagnosis at an autism treatment center is essential. 

Autism Related Conditions

Children with autism exhibit a large spectrum of disorders. These may include attention disorders, sensory or regulatory conditions, etc., which involve a number of different problems, including:

• A tendency to avoid interaction
• Limited eye contact 
• Failure to develop pretend play
• Problems following simple directions
• Do not point to show things
• Poor coordination
• Echolalia or repeating what has been said
• Hates being hugged or touched

At the autism treatment center, a child with autism receives a diagnosis based on the behaviors and symptoms he/she shows. As autism is said to be a spectrum of disorders, each child is diagnosed with a unique pattern of development and functioning.  

What causes autism?

Autism is the result of a neurologic abnormality, still findings points to:

•  Genetic defect: A number of different genes when combined, increase the risk of the child getting autism. When having one child with autism, the risk of having another with autism is low. 
• Medical condition: Untreated metabolic disorders, congenital infections (rubella), genetic disorders (X syndrome), underdeveloped brain (cerebral palsy and autism) or neurologic disorders acquired before or after birth. 

Environmental factors and exposures toxins may result in an increased risk of autism.

Cell Therapy To Combat Autism

Mesenchymal stem or stromal cells derived from marrow tissue show great therapeutic potential in cell treatment. They have the potential to multiply and differentiate into any cell type while also adapting their properties. The ability to differentiate helps in replacing the dead cells of the tissue, healing the injury and reconstructing the lost functionality.   

To receive the best autism treatment in India, people from other continents flock to NeuroGen Brain and Spine Institute to meet Dr. Alok Sharma and discuss the treatment options to treat their children or kins. The fame of Dr. Sharma has spread throughout the world for his expertise in treating autism with stem cells. An expert neurosurgeon, he along with his team of doctors, nurses and therapists provide comprehensive care for individuals with spinal cord injuries, muscular diseases, and neurological disorders. From diagnosis to treatment and recovery, the hospital provides all facilities under one roof.   

Therapy with marrow-derived autologous stem cells is the best autism treatment in India. These cells do not invoke any risk of rejection in the body as compared to the allogeneic (donated) stem cells.

Muscular Dystrophy Treatment at Neurogen Hospital

Muscular dystrophy is a myriad of progressive diseases that result in weakness and loss of muscle mass. It is caused due to genes
mutations which interfere with the production of ‘dystrophin’, a protein needed to build healthy muscle.
There is no complete cure for muscular dystrophy, but with cell therapy for muscular dystrophy, there is a possibility of managing
the symptoms and slowing down the muscle deterioration. 

The mutation of the genes and loss of dystrophin leads to a sequence of dysfunctional developments causing severe and progressive
muscle-wasting skeletal muscles and heart muscles. These skeletal muscles are responsible for voluntary body movements. As they
weaken people with muscular dystrophy lose their ability to walk or do manual work. They experience muscle spasms (twitches or cramps)
that are painful and make fine muscle control more difficult. If the patients do not receive treatment, they may develop slack muscle
and an enlarged heart with chances of heart failure.

Signs and Symptoms 

• Loss of balance resulting in frequent falls

• Difficulty when rising from a lying or sitting position

• Unable to run or jump

• Walk with a waddling gait

• Walk on the toes

• Enlarged calf muscles

• Frequent muscle pain 

• Muscle stiffness

• Learning disabilities

Muscular dystrophy treatment with stem cells is done at NeuroGen Brain and Spine Institute by renowned surgeons guided by Dr. Alok Sharma.
With years of experience and expertise, Dr. Alok Sharma is amongst the top-ranked neurosurgeon in India. Holding a supreme position in NGBSI,
his area of specialization is neurosurgery with stem cells. 

The treatment for muscular dystrophy involves the use of bone marrow-derived mesenchymal stem cells. The regenerative and anti-inflammatory properties of stem cells are considered as a good treatment option for muscular dystrophy.  The doctor at the hospital confirms that cell therapy for muscular dystrophy has the potential to create muscle protein and also helps to halt the progressive muscle deterioration. For treating the patients, the doctors remove the bone marrow from the hip bone of the patient. The marrow tissue is subjected to a stem cell separation procedure at their fully equipped GPL and GMP laboratory. The separated useful stem cells are administered into the muscles points using a thin needle.

The healthy stem cells, transplanted into the muscles, generate healthy cells into the diseased muscle. They substantially improve the ability of the muscles by replenishing the weak cell pool, and also provide a continuous generation of healthy stem cells. Thus, muscular dystrophy treatment with mesenchymal stem cells repairs the muscle without fear of cell rejection and tumor formation.

Successful cell therapy for muscular dystrophy should be done before the muscle cells get completely depleted.

Autologous Cell Transplant for People with Stroke

A stroke is a ‘brain attack’ which occurs if the blood flow to an area of the brain is cut off. The brain cells begin to die as they are deprived
of fresh oxygen supply. As they die, their ability to control the person’s memory and muscle movement get completely lost. The level of
stroke severity depends on the area and the extent of brain damage. Thus, stroke is a neurological disorder caused by the loss of neurons
or glial cells of the brain. Cell treatment for stroke is an innovative therapy to treat people with their own stem cells. 

Types of Stroke

Haemorrhagic stroke

A haemorrhagic stroke occur when weak blood vessels burst to spill blood. This results in the swelling and damage of the tissue and cells. 

Ischemic Stroke

If the blood vessels become narrow or get by a blood clot (ischemic), it causes reduced fresh blood supply to the brain.  

A transient ischemic attack (TIA) 

A transient ischemic attack is just like a stroke. It has similar symptoms but lasts only for a short period. This ‘mini-stroke’ causes no permanent
damage but acts as a warning for a serious stroke.

Cell treatment for stroke helps to generate new neurons and glia in patients suffering from a stroke. Stem cell-based therapy at
NeuroGen Brain and Spine Institute is accomplished using mesenchymal stem cells to treat a variety of damaged brain tissues.
Easily accessible in the marrow tissue, these cells are exceedingly suitable for autologous cell-based therapies. As they are derived
from the patient’s own body (autologous), they do not face issues like rejection while merging with other stem cells.  

Thus, for stroke cell treatment has helped in preventing the death of brain cells by promoting regeneration and repair of
defective tissues, nerve, and cells.  

Transplantation of mesenchymal stem cells involves just three simple steps:

• Collecting the marrow from the hip bone of the patient
• Purifying and filtering the cells through ‘density gradient centrifugation’ procedure
• Infusion of the filtered stem cells after being diluted in CSF 

At the hospital, for people with stroke cell treatment is an intrathecal administration of mesenchymal stem cells in the spinal area.

When infused in the body, these cells migrate through the vertebral canal to reach the site of injured brain tissue.
They begin their healing process to stop further tissue deterioration and to generate new cells to replace the dead ones. As the tissue
gets healed the brain regains its lost plasticity.

Thus, cell treatment for stroke is a promising way of promoting the interest of people towards regenerative medicine