Muscle Regeneration With Cell Therapy

Muscular dystrophy is a varied collection of neuromuscular disorders that result in progressive muscle weakening and wasting. The disorders differ depending on their severity and the muscle types affected. Duchenne muscular dystrophy, an X-linked genetic disorder, is a common form of muscular dystrophy.

Muscular dystrophy occurs due to spontaneous mutation or inherited mutation in the dystrophin gene which results in the loss of dystrophin protein. Dystrophin is an important cytoskeletal protein responsible for the maintenance of muscle cell stability or integrity. Without adequate dystrophin, muscle cells degenerate rendering the person helpless.

For satisfactory treatment, cell therapy for muscular dystrophy is done with autologous stem cells isolated from the patient’s bone marrow. To date, where many treatment methods have failed, stem cells with their multiple growth factors and healing potential, promote muscle regeneration. 

Cell treatment, for muscular dystrophy, has proved to be the best option to treat muscular dystrophy with success. To correct the dystrophic insufficiency, the transplanted stem cells merge with the host cells to form new myotubes. This fusion contributes to the production of functional dystrophin protein. Stem cell based therapy for muscular dystrophy is beneficial via autologous stem cell transfer strategy. For this process, the marrow is collected from the patient’s hip bone. The collected marrow tissue is filtered to separate the active stem cells. The collected stem cells are improved/treated to restore dystrophin expression and are subsequently re-implanted into the required muscle points of the patient.

Advantage Of Autologous Transplant

As autologous cell therapy for muscular dystrophy is done with stem cells derived from the patient, they are unlikely to elicit an adverse immune response. However, in an allogenic cell transplant, the patient risks immune rejection due to issues of donor compatibility.  

Neurogen Brain and Spine Institute based in Mumbai, offers the best cell treatment for muscular dystrophy and other neurological disorders such as autism, dementia, cerebral palsy and stroke. The neurosurgeons of the hospital state that 90% of improvement was seen in their patients after cell treatment.

Patients treated have shown improvement in their standing posture, trunk stability, and needed less support while walking. They exhibited an improved standing and walking balance and no more falling due to the buckling of knees. There was an increase in muscle strength of ankle muscles and the patient could climb up and down the stairs with ease and less support.